Biomedical Science

In this work, we reported a strategy incorporating neutralizing antibodies conjugated to the surface of a photothermal nanoparticle (NP) to capture and inactivate SARS-CoV-2.

In this work, we showed that functionalized nanoparticles, termed “Nanotraps,” completely inhibited SARS-CoV-2 infection by blocking the interaction between the spike protein of SARS-CoV-2 and the ACE2 of host cells.

We described here a light-fueled liquid-metal transformer for effective endosomal escape-facilitated cargo delivery via a chemical-mechanical process. Such liquid metal transformer could absorb and convert photoenergy to drive the simultaneous phase separation and morphological transformation from nanospheres to hollow nanorods to promote endosomal escape of payloads.

We have developed a new liquid metal-based drug delivery platform for anticancer therapy. The liquid-metal nanomedicines are able to fuse for promoting drug release and eventually degrade under a mild acidic environment.